At Home Lab Tests

SEE WHAT YOUR GUT IS ACTUALLY DOING

Your gut is the foundation of your energy, mood, immunity, hormones, and metabolism, and most of what drives symptoms there stays invisible until you measure it. These at home panels map your microbiome, your food reactivity, and the integrity of your intestinal barrier, then turn that data into a clear, personalized direction. Shipped to your door, with an optional educational results review from Jess. United States only.

All collected at home. Simple finger prick, saliva swab, or stool sample, no clinic visit needed.

Order A Lab

Test, Do Not Guess

WHAT THESE TESTS REVEAL

Your gut lining is one cell thick. Tight junction proteins control what passes through: occludin seals the gaps, zonulin opens them. When those junctions loosen, bacterial toxins, undigested food, and waste leak into the bloodstream and set off chronic low-grade inflammation that shows up as fatigue, brain fog, breakouts, joint pain, and mood swings, symptoms that almost never point straight at the gut.

Food sensitivities keep the lining irritated and prevent it from healing. Your mouth plays a role too: periodontal bacteria can travel to the gut and break down the same barrier from the other direction, and candida overgrowth damages the lining directly. Testing maps all three doors, your food triggers, your gut microbiome, and your oral bacteria, so you fix the right things in the right order instead of guessing for months.

What Jess recommends

Start with the KBMO FIT 176 + Gut Barrier Panel and the Oral Microbiome Profile. That covers the most food triggers, the state of your gut barrier, and the bacteria in your mouth in one pass. If you are still not where you want to be after a few months, add the GI-MAP to see exactly what is living inside your gut.

The Science

Your gut barrier and what breaks it

The lining of your small intestine is only one cell thick, and proteins called tight junctions act as the seals between those cells. Occludin is one of those seals. Another protein, zonulin, can pull the junctions open. When they loosen (increased intestinal permeability), partly digested food, bacterial waste, and toxins start slipping through and setting off the immune system [1][2][3].

One of the most studied things that slips through is LPS (lipopolysaccharide), a toxin shed by certain gut bacteria. Even tiny amounts in the blood, called metabolic endotoxemia, are enough to drive chronic inflammation [4][5]. Higher LPS levels turn up across obesity, type 2 diabetes, fatty liver, and heart disease, which is why more research now points to the gut barrier as an upstream cause of inflammation rather than a side effect [4][5][6].

Permeability, inflammation, and autoimmunity

If you are genetically prone to it, a leaky barrier is a recognized part of how autoimmune disease gets going. When undigested proteins, bacterial fragments, and toxins reach the bloodstream, the immune system can begin attacking its own tissue [3][7]. This is the work of Dr. Alessio Fasano, who discovered zonulin and showed how it acts as a doorway to inflammation and autoimmunity. Increased permeability has been documented in IBS, inflammatory bowel disease, and type 1 diabetes [10].

Food sensitivities and why testing beats guessing

If you keep eating foods your immune system reacts to, the gut lining stays inflamed, feeding permeability and preventing healing [8][9]. Normally, finding your triggers means a long elimination diet: cutting out whole food groups and slowly reintroducing them. Testing skips most of that. You find out exactly which foods are the problem and just avoid those. The one exception is candida: if you have an overgrowth, you still need to avoid the foods that feed it while you bring it back into balance, regardless of your sensitivity results.

The oral-gut connection

Your mouth has a barrier too. With gum disease, oral bacteria and their toxins get into the bloodstream. The worst, led by Porphyromonas gingivalis, does not stay in your mouth: it disrupts the gut itself, lowering tight junction proteins and driving the same endotoxemia [11][12][13]. P. gingivalis has also been found in clogged arteries and in more than 90 percent of Alzheimer's brains [21][22].

Candida makes it worse. It damages the intestinal lining directly with its toxin candidalysin [15], and in the mouth it partners with P. gingivalis, building shared biofilms and hiding bacteria from your immune system [14]. Together they pry the barrier open and hold it there, which is a big reason candida is so hard to shake and why a damaged gut struggles to heal while the mouth is still inflamed.

Signs you can check right now

Healthy gums do not bleed, ever. If yours bleed when you floss or brush, that is inflammation and one of the earliest signs of gum disease [16]. A thick white coating on your tongue can point to oral candida [17]. Three or more yeast infections in a year is candida about nine times out of ten [18]. Researchers are also taking candida's link to cancer seriously: it produces carcinogenic compounds like acetaldehyde, with the strongest evidence tying it to oral cancer [19][20].

What each test measures

The KBMO FIT panels (22, 132, or 176 foods), each paired with a Gut Barrier Panel, measure your immune reactivity to specific foods and additives plus how leaky the lining is. The GI-MAP is a DNA-based stool test that maps bacteria, yeast, parasites, and markers of digestion, inflammation, and immune activity, with optional add-ons for zonulin and StoolOMX. The Oral Microbiome Profile maps the bacteria in your mouth, including the periodontal pathogens. Three doors: your food, your gut, and your mouth.

The Science

REFERENCES

  1. Chelakkot C, Ghim J, Ryu SH. Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med. 2018. nature.com
  2. Al-Sadi R, et al. Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2011. PMC3119114
  3. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011. physiology.org
  4. Page MJ, Kell DB, Pretorius E. The role of lipopolysaccharide-induced cell signalling in chronic inflammation. 2022. sagepub.com
  5. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. 2012. PubMed 22717075
  6. Endotoxemia of metabolic syndrome: a pivotal mediator of meta-inflammation. PubMed 25162769
  7. Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012. springer.com
  8. Associations between food-specific IgG antibodies and intestinal permeability biomarkers. Front Nutr. 2022. frontiersin.org
  9. Food-specific IgGs are highly increased in the sera of patients with inflammatory bowel disease and are clinically relevant to the pathogenesis. 2018. PMC6207831
  10. Camilleri M. Leaky gut syndrome: myths and management. Gastroenterol Hepatol (NY). 2024. PMC11345991
  11. Socransky SS, Haffajee AD, et al. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998. Wiley
  12. Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function. PLoS One. 2015. PMC4517782
  13. Can oral bacteria affect the microbiome of the gut? J Oral Microbiol. 2019. tandfonline.com
  14. Adhesive protein-mediated cross-talk between Candida albicans and Porphyromonas gingivalis in dual-species biofilm. Sci Rep. 2019. nature.com
  15. Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. 2018. PMC5989070
  16. Gum (periodontal) disease: causes, symptoms and treatment. Cleveland Clinic. clevelandclinic.org
  17. Candida infection: thrush. Cedars-Sinai. cedars-sinai.org
  18. A comprehensive overview of Candida albicans as the leading pathogen in vulvovaginal candidiasis. PMC12471164
  19. Is Candida albicans a contributor to cancer? A critical review based on the current evidence. 2023. PubMed 37028206
  20. Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans. 2013. PubMed 23445445
  21. Dominy SS, et al. Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019. science.org
  22. Porphyromonas gingivalis: a potential trigger of neurodegenerative and cardiovascular disease. Front Immunol. 2025. frontiersin.org

These references support the educational mechanisms described above. They are not claims that any test diagnoses, treats, or cures disease.

How It Works

FROM ORDER TO ANSWERS

01
Choose and check out
Pick your labs, add an optional results review, and pay through secure checkout.
02
Jess places the order
Jess orders your test through the lab network and the kit ships to your door.
03
Collect and mail back
Take your sample at home and send it back to the lab in the prepaid packaging.
04
Results and review
Your results come back, with the educational review you selected if you added one.

Order Your Labs

BUILD YOUR LAB ORDER

Choose your labs, pick a shipping speed and an optional results review, and complete your details. Every fee is shown before you pay, and the labs are passed through at our cost with no markup. Our only charge is the optional results review.

1. Choose Your Labs

Pick one or more. Prices shown are the lab plus its pass-through fees. Shipping, your optional review, and tax are added below. All labs ship within the United States only.

Dante Labs Whole Genome TestDante Labs · you check out on their siteDNA SequencingFull whole genome sequencing from Dante Labs: your complete DNA, not just the common variants. A deep look at health risks, traits, pharmacogenomics, and ancestry, with lifetime access to your raw data. Every sample is sequenced at about 30x coverage, reading your DNA roughly 30 times over so the results come back accurate. Ordered, sequenced, and shipped directly by Dante Labs.Code UPGRADEYOU for 10% off at Dante Labs

2. Shipping Speed

Applied per lab, since each lab ships from its own provider.

3. Results Review With Jess

An educational wellness review of your markers with lifestyle and nutrition context. Not a diagnosis or medical advice.

4. Who The Test Is For

The lab requires the legal name, date of birth, and gender of the person being tested, used for accurate reference ranges. Your sensitive details are encrypted, sent privately to Jess to place your order, and never stored in your browser.

5. Where To Ship The Kit

United States addresses only. This is where the test kit is mailed.

Select a lab above to see your itemized total.

Before You Order

LAB TESTING QUESTIONS

How does ordering a lab here work?

You choose your labs and complete the intake here, then pay through our secure checkout. Jess places the order with the lab and the test kit ships directly to your address. You collect your sample at home, mail it back to the lab in the prepaid packaging, and your results come back through Jess, along with any review you selected.

Do I need my own doctor to order?

No. A licensed physician in the lab ordering network authorizes the requisition, which is what the lab authorization fee covers. You do not need to bring your own provider.

Who can order, and where do you ship?

Lab testing is available to adults 18 and older with a United States shipping address only. The labs accept United States samples only, so we cannot ship kits internationally.

Why is shipping charged per lab?

Each lab is fulfilled by its own provider (KBMO Diagnostics, US BioTek, and Diagnostic Solutions Laboratory), so each kit ships separately and carries its own shipping.

What is the results review?

It is an educational wellness review of your markers with lifestyle and nutrition context, plus questions to bring to your doctor. The written review is per lab, and the live walkthrough is a single 30 minute call covering all of your results. It is educational support, not a medical diagnosis or treatment.

Are lab orders refundable?

Once an order is placed with the lab it cannot be refunded, because the test is a hard cost the moment it is ordered. Please choose carefully before checking out.

Do you mark up the lab tests?

No. We pass each lab through at our cost, the test plus the lab's own fees and shipping, with no markup added to the test itself. Our only charge is the optional educational results review you choose, plus a small card-processing line.

How is my information handled?

Your intake, including date of birth and address, is encrypted, sent only to Jess so the order can be placed, and is never stored in your browser. Sensitive details are deliberately kept out of the payment processor, and if you choose to save your details to your account they are encrypted there too. See the privacy policy for more.

Lab testing and any results review offered here are for educational and wellness purposes and are not medical diagnosis, treatment, or a substitute for care from a licensed physician. Testing is available to United States residents 18 and older only. Read the full disclaimer.